Background: Worldwide, coronavirus disease 2019 ( COVID-19 ) has been announced as the most disturbing event that put people under major stress and added additional complexity to newly mothers. Aim: The study aimed to assess newly mothers` preventive practices regarding COVID-19 pandemic. Method: A descriptive cross sectional study was utilized. Study subjects: A convenient sample of 192 newly mothers attended at the Governmental Health Unit in Aga city, Dakahlia, Egypt, during the six wave of COVID-19 pandemic (July 2022 to September 2022). Data collection tool: A structured interview questionnaire was utilized. Results: The study result revealed that around two third of them reported that they didn`t wash hands before feeding the baby, didn`t sterilize the bottle for the baby and didn`t wear a face mask when breastfeeding baby. Conclusion: A bout half of the studied newly mothers had poor preventive practices regarding COVID-19 during the pandemic. Recommendation: Raising newly mothers` awareness regarding preventive practices during COVID-19 pandemic.