Background: Breast self-examination (BSE) is a simple screening tool that has an effective role in early
detection of any abnormalities in the breasts. Aim: The current study aimed to assess nurse's practice regarding breast
self-examination. Study design: A ddescriptive cross sectional study design was utilized. Setting: The study was
conducted at Temai El-Amdid Central Hospital, Mansoura city, Dakahlia Governorate. Sample type: A convenient
sample was used. Study subjects: the study subjects included 193 nurses who were working at the previous mentioned
setting. Tools: Two tools were used for data collection; A structured interview questionnaire and Observational
checklist. Results: The study showed that more than half of the studied nurses knew that the suitable time for BSE, and
most of them knew that BSE is important for early detection of breast cancer. Also, about two-thirds of them correctly
inspect both breasts for symmetrical shape, size and inspect nipple & areola. Despite, the majority of the studied nurse's
correctly palpated breasts by the palmer surface, but they inappropriately verified any mass for site tenderness, size, and
shape. Furthermore, most of them correctly expressed the nipples for any discharge, and examined the axilla area for any
nodes. Conclusion: About two-thirds of the studied nurses had a satisfactory level regarding inspection, while most of
them had unsatisfactory level regarding breast palpation. In addition, there was a significant relationship between
average scores of practice and nurses who had personal or family history of breast tumors. Recommendations: Training
sessions including (simulator, videos, and films) should be designed to enhance nurses' competences regarding BSE
practice.