Background: Health care workers, especially nurses, are at risk of acquiring COVID 19 infection through occupational
exposure. The primary transmission of COVID-19 is from person-to-person through respiratory droplets. Adherence to
infection prevention control measures remain the best weapon to protect health care worker against COVID 19. Aim:
Evaluate nurses' knowledge and adherence to infection prevention control measures during caring for COVID 19
patients. Method: A descriptive cross-sectional design used throughout this study. A convenient sample technique was
utilized on 106 nurses in the Convalescence building at Mansoura University Hospital. Data was collected using 2 tools,
COVID-19 Nurse's Knowledge Questionnaire and COVID -19 Infection Prevention Control Measures Observational
Checklist. Results: It was observed that 53.8% of the studied nurses had average knowledge level and 52.8% of them
had poor adherence to infection prevention control measures. It was noticed that, there was strong positive correlation
found between nurse's total adherence, knowledge level and infection with COVID 19. Conclusion: most studied nurses
had average knowledge level and poor adherence to COVID 19 infection prevention control measures
Recommendation: Adequately planned training programs and refreshing training is imperative to improve the level of
nurses knowledge and adherence to infection prevention control measures during caring for covid19 patient's.