Background: Today, gastrointestinal endoscopy is the most commonly used procedure in medicine. for the most
accurate diagnosis and treatment of patients suffering from gastrointestinal disorders Thus, anxiety as a negative
influence or side effect of endoscopy reduces patients' acceptance ability. Aim: To determine the effect of nurse led
intervention on knowledge and anxiety among hepatic patients undergoing gastrointestinal endoscopy. Design: A quasiexperimental,
pre and posttest design with a control group was used. Setting: The study was conducted at ElMahalla
Hepatology Educational Hospital, Egypt. Methods: two tools were used, structured interview questionnaire to assess
knowledge and demographic data of patients and Beck Anxiety Inventory scale to assess patients anxiety. Results: This
study clarified that the effect of the nurse led intervention was positive and clear. It also shows that there was good
improvement with high significant differences in knowledge and anxiety in study group compared to their control post
intervention (P<0.001). Conclusion: The findings of the study showed that the anxiety state was found to be more
common among the patients subjected to endoscopy procedure. Providing educational program was an effective method
to increase awareness and decrease the anxiety of the patients subjected to gastroscopy. Recommendations: Replication
of the current study on a larger probability sample from different geographical areas, to achieve generalizable results.