Background: Most cervical cancers are caused by a long-term infection with high-risk HPV types. HPV infection is
one of the most common sexually transmitted infections in the world. HPV vaccines work best when given before HPV
infection. Aim: The study aimed to assess of university student's attitude towards HPV infection, vaccination and their
vaccine acceptability. Design: The researchers used a descriptive cross sectional study design. Setting: This research
was carried out at Mansoura University's faculties in Mansoura, Dakahlia Governorate, Egypt. Mansoura University has
18 faculties .Sample type: A convenient sample was utilized. Study Sample: This study sample included 323 male &
female university students who were chosen from different faculties. Tools: Three tools were used; a structured
interview questionnaire, student's attitude Modified Likert's Scale about human papilloma virus infection& its
vaccination and HPV vaccination acceptability, barriers and causes of refuse. Results: Most (93.5%) of students had
negative attitude while, (6.5%) of them had a favorable opinion of HPV infection and vaccination, nearly one quarter
(23.5%) of them accepted to take the vaccine while, more than three quarters (76.5%) of them refused HPV vaccination.
The total attitude score and total acceptability score had a highly statistically significant relationship (p0.001).
Conclusion: University Students had negative attitude towards HPV infection & vaccination and more than three
quarters of them refused HPV vaccination. Recommendation: Providing students with health education to improve their
attitude and increase their desire to receive the HPV vaccine as well as their knowledge of HPV infection and
vaccination.