Background: Traumatic brain injury (TBI) is a prominent cause of death and disability globally, with long-term
consequences. For the millions of TBI survivors, the implementation of new guidelines for neuroprotection and
restoration may enhance TBI patient outcomes. Aim: This study aimed to assess the effect of care bundle
implementation on TBI patients' physiological parameters. Method: A quasi-experimental design was used to conduct
this study in the emergency department of the Emergency Hospital at Mansoura University. A sample of 52 patients was
randomly assigned to the bundle group (n = 26) or the control group (n = 26). The bundle group received the bundle and the control group received routine care. Data were collected using traumatic brain injury patients' outcome tool. Results: The findings showed improvement in the bundle group patients' physiological parameters, but not statistically
significant, except for oxygen saturation (P= 0.049). Conclusion: The application of the evidence-based care bundle can
improve TBI patients' physiological parameters. Recommendations: Nurses in emergency departments can integrate
this bundle into TBI patient care. Moreover, assessment of the long-term impact of this bundle in intensive care units and
rehabilitation centers is urged.