Background: Hematopoietic stem cell transplantation (HCT) is the curative treatment of choice for many malignant
and nonmalignant hematologic disorders, nurses play a crucial role in patients' care. So, they must be knowledgeable
and aware of recent trends in diagnosis and treatment, competent and able to apply their knowledge of nursing into
practice. Aim: evaluate the effect of an educational program on knowledge, and performance of nurses caring for
patients undergoing stem cell transplantation. Sample: Convenient sample of all available nurses (30 nurses) in stem
cell transplantation unite, Oncology Center, affiliated to Mansoura University Hospitals. Methodology: Quasi–
experimental design was used. Tools: Two tools were used Structured interviewing questionnaire, and performance
chick list. Results: that most of the studied nurses (80%) had poor knowledge level before application of educational
program after application of educational intervention most of the studied nurses (83.7%) become knowledgeable about
stem cell transplantation. Also, performance level of the studied nurses about stem cell transplantation reach 90% after
application of educational program. Conclusion: there were highly significant development in nurses' knowledge and
performance after application of educational program about stem cell transplantation. Recommendations: continuous
nursing education and training programs should be implemented regularly in stem cell transplantation unit.