Background: Fatigue is one of the most prominent and disabling symptoms of multiple sclerosis (MS). It occurs in 75-
95% of MS patients. The nurse must be aware of both pharmacological and non-pharmacological management of
Multiple Sclerosis related fatigue (MSRF). Strength and Balance training (SBT) is one of exercises which have proven to
be promising nonpharmacological interventions for MS patients who have fatigue complaint. Therefore, the aim of the
study, was to evaluate the effect of strength and balance training on fatigue in patients with multiple sclerosis.
Methodology, Quasi–experimental study with a purposive sample of totally 90 MS patients from both gender who were
admitted to neurology department at Mansoura University Hospital was enrolled in this study. Patients were assigned
equally to control and intervention group. Data were collected using three tools: Structured Interview Questionnaire,
Modified Fatigue Impact Scale and Strength and Balance Training Observational Checklist. Results, there was a
significant decrease in fatigue among the study group who practiced strength and balance training compared to control
group according to the Modified Fatigue Impact Scale (p-value ≤ 0.05). Conclusion, the study concluded that the
strength and balance training have a significant effect in reducing fatigue among MS patients.