ABSTRACT: Obesity represents a global challenge because its effect on life style of many peoples suffering from it. The present study aimed to evaluate the role of some adipose tissue hormones and enzymes level in obese rats associated with cardiovascular diseases, and to evaluate therapeutic role of some medicinal plants (garlic and green tea). A number of 80 male albino rats divided to 8 groups: G1 (normal group), G2 Non treated (fat lard feeding) group, G3 and G4 (fat lard feeding) for one month followed by treatment with green tea for a another month with 1 ml and 2ml dose of extract respectively, G5 and G6 (fat lard feeding) group for one month followed by treatment garlic for another month with 1ml and 2ml of extract respectively. G7 and G8 (fat lard feeding) group for one month , and treatment with mixture of green tea and garlic extract for another month with1ml mixture and 2ml mixture of each respectively . At the end of experiment , the serum collected for analyses of the foldaway parameters (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, nitric oxide NO, lactate dehydrogenase LDH, aspartate transaminase AST and thyroid stimulating hormones (TSH ,T3, T4).