ABSTRACT: The present study was designed to investigate the chemical composition, determination the phenolic contents in plant extracts and studying the cytotoxic effects of plant seeds against land snail. The plants under study were Portulaca oleracea and Cichorium intybus. Our results could be summarized that Portulaca oleracea (purslane) contain ash, fiber, crude lipids, protein and carbohydrate 2.15, 33, 26, 11.6 and 60.25 % and Cichorium intybus (chicory) contain 1.65, 35, 19, 10 and 69.35 % respectively. Purslane contain 13 phenolic compounds, meanwhile chicory contain 16 phenolic compounds, the main compounds in purslane seed extract were coumaric acid (129.62 μg/ml) and coffeic acid (108.98 μg/ml) and main compounds in chicory were naringenin (3631.04 μg/ml) and chlorogenic acid (2395.18 μg/ml). Results showed cytotoxic effects ofextractsof purslane and chicory seeds on the land snails iv stage, whereas increases theextract concentration from (25 to 100%) led to decrease the egg ms/snail, egg no./ms, egg no. / snail, Inc. period (day) and hatch rate.