Our topic in this  research is related to protecting  the liver  from  damage that can be caused by the presence of oxidized substances, which may cause liver damage,  which reduces its efficiency as we looked  for  natural  substances  that are may have a positive effects on the liver and most internal organs without causing  a bad  side effects of organism. The target of this study is to evaluate the impact of ginger extracts on the protection of the liver affected by hydrogen peroxide in experiential rats, depending on the content of these extracts from total phenolic compounds and flavonoids. The experiment is based on two main points: (A) determine the chemical composition of ginger rhizomes; (B) evaluate the effect of ethanol and acetone extracts of ginger rhizomes against hydrogen peroxide (0.5%). Our results showed that, ginger rhizomes contained: 21.2% protein, 0.83% ash, 0.58% fiber, 6.98% fat, 58.9% total carbohydrates and 550mg/100g total phenolics. HPLC analysis for the ethanolic extract of ginger rhizome showed that its contain 17 phenolic compounds from which gingerols was the main one (8.77%) followed by zingerone (6.39%), while shogaols, vanillin, taxifolin, ferulic acid and cinnamic acid were in a moderate amount (4.82%, 3.7%, 3.4%, 3.08% and 2.0%), respectively. While, acetone extract of ginger rhizome contain 16 phenolic compounds, the main one is gingerols (9.6%), followed by zingeroene (7.0%), kaempferol (5.52%), shogaols (5.46%), vanillin (4.63%), taxifolin (4.53%), gallic acid(4.45%), ferulic acid (4.2%), cinnamic acid  (2.63%) and syringic acid (1.96%). There are six group as follows: negative control (NC), PC (0.5% H₂O₂), EG1 (0.5% H₂O₂ +0.05% ethanoic extract of ginger), EG2 (0.5% H₂O₂ +0.1% ethanoic extract of ginger), AG1 ((0.5% H₂O₂ +0.05% acetone extract of ginger) and AG2 (0.5% H₂O₂ +0.1% acetone extract of ginger). All ginger treatments improve liver functions (albumin, total protein, ALT, AST and ALP activities). The same effect notice in kidney functions (urea and creatinine). All treated groups EG1, EG2, AG1 and AG2 showed a high significant decrease in MDA levels compared with PC, with a comparative advantage to EG2 and AG2. EG1, EG2, AG1 and AG2 groups showed a high significant decrease in catalase activity compared with PC, with a comparative advantage to EG2 and AG2 Finally, it can be recommended to use ginger in diets because of its extracts (ethanolic and acetone) that are characterized by a high content of natural antioxidants, as well as the positive role of these extracts in combating free radicals in vivo when tested on experimental rats.