Spray painting workers in car and furniture workshops are occupationally exposed to intense painting vapors. The main objective of this study is to evaluate health risk resulted from exposure to paintings spray, especially related to the included cadmium (Cd) and lead (Pb) metals. The studied groups (15-60) years old, were all non-smoker males; 20 workers selected from 6 car painting workshops, 30 from 6 furniture painting workshops and 20 healthy subjects away from exposure to paintings or other chemicals represented control group. Results showed significantly increased levels of Cd and Pb in serum and urine of car and furniture painters compared to control subjects, where metals concentration in car workers were more than furniture ones. Results showed significant decrease in hemoglobin content, red blood cells and platelets count, along with significant increase in total leucocytes count in car and furniture painters compared to unexposed subjects. In parallel, disturbed liver and kidney functions represented by significant reduction in serum total protein and albumin contents, along with remarkable elevation in aspartate aminotransferase, alanine aminotransferase, creatinine and uric acid. These were accompanied by significant increase in urine protein and albumin contents, as well as creatinine were observed in exposed groups compared to control subjects. However, serum acetylcholinesterase levels decreased significantly in both car and furniture painters. So, car and furniture painters are in potential risk lying through working environment, which requires attention, mitigations, and management to protect their health.