2 million new cases in 2019. Phytochemicals have been used in traditional medicine for centuries, however, they recently gained attention in cancer research due to their potent antioxidant, anti-inflammatory, and immunomodulatory effects. This study aimed to elucidate the prophylactic and/or therapeutic effect of a phytochemical combination “Breast safeguard" on mammary adenocarcinoma in vivo model of Ehrlich cells. Thirty mice were randomized into three groups of Ehrlich group, the Prophylactic group, and the BSG-treated group. A marked enhancement in the mice survival rate and a significant reduction in tumor size was recognized after two weeks of treatment. And TNF-α, and Bax/Bcl2 ratio markers for cancer prognosis and apoptosis, the results showed a significant decrease in tumor volume in the protective group than in the treated one. This phytochemicals combination showed a potent anticancer characteristic by inhibiting Ehrlich tumor proliferation and induction of cell apoptosis indicating its possible use as a promising prophylactic drug in prospective studies