Over the last decades, cancer stem cells (CSCs) have been a major hurdle challenging every oncologist worldwide. Despite the anticancer effects of the adjuvant therapy protocols, they still facing major challenges include harmful side effects and poor free survival period that is ascribed to the EMT and metastasis. Recently, alternative approaches of treatment using plant extracted phytochemicals that originally exist in the dietary food and plant roots have proved their anticancer effects with extra advantage that they have no side effects on the healthy organs. In the current study, a combination of phytochemicals has been evaluated as an anticancer, anti-metastatic drug for the highly invasive breast cancer cells MDA-MB231. The data revealed that the low dose of the combination has significantly decreased the expression of the migratory genes (N- Cadherin and Vimentin) after 72hr of exposure to the combination. Furthermore, the low dose has also reduced the proliferation rate of the MDA-MB231 cells after 6 days. This study demonstrates that using low doses of phytochemicals for a longer time may be a promising protocol for inhibiting cancer proliferation and metastasis.