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Effective Management of Acute Aluminum Phosphide Poisoning in Pregnancy: A Case Study of Dual Therapy Efficacy and Collaborative Care

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Last updated: 26 Dec 2024

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Research articles (original articles)

Abstract

Aluminum phosphide (AlP) poisoning is a significant public health concern, particularly in developing countries where it is easily accessible. This case report discusses the successful management of acute AlP poisoning in a pregnant woman at 28 weeks gestation. Initially presenting with vomiting and abdominal pain and discomfort, the patient remained stable throughout. Metabolic acidosis, identified through arterial blood gas analysis, prompted bicarbonate administration. The application of dual therapy with N-acetylcysteine (NAC) and Coenzyme Q10 (CoQ10) effectively countered oxidative stress, contributing to the patient's stabilization. Collaborative interdisciplinary care played a crucial role in ensuring the well-being of both the mother and fetus, ultimately resulting in a favorable outcome upon discharge. This case highlights the effectiveness of therapeutic interventions and underscores the pivotal importance of interdisciplinary cooperation in managing acute AlP poisoning. Such instances reinforce the significance of a rapid and coordinated response to mitigate the potentially fatal consequences of poisoning incidents.

DOI

10.21608/jmalexu.2024.281601.1017

Keywords

Aluminum phosphide poisoning, pregnant woman, N-acetylcysteine, Coenzyme Q10, dual therapy

Authors

First Name

Maii

Last Name

Henaidy

MiddleName

-

Affiliation

Forensic medicine and clinical toxicology department, Faculty of medicine, Alexandria University, Alexandria, Egypt

Email

maiihenaidy@gmail.com

City

-

Orcid

-

First Name

Ashraf

Last Name

Noah

MiddleName

-

Affiliation

Clinical Research Administration, Alexandria Directorate of Health Affairs, Egyptian Ministry of Health and Population, Alexandria, Egypt

Email

mri.ashrafnoah4.8.23@alexu.edu.eg

City

Alexandria

Orcid

0009-0009-0703-0222

First Name

Mohamed

Last Name

El-Zahabi

MiddleName

Ayman

Affiliation

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Email

malzahaby@azhar.edu.eg

City

-

Orcid

-

First Name

Hany

Last Name

Gemeah

MiddleName

Mustafa

Affiliation

Directorate of Health Affairs in Buhaira-Clinical Research Department, Ministry of Health and Population, Damanhur, Egypt

Email

drgemeah@gmail.com

City

-

Orcid

-

First Name

Amal

Last Name

Shouair

MiddleName

M.

Affiliation

Directorate of Health Affairs in Buhaira-Clinical Research Department, Ministry of Health and Population, Damanhur, Egypt

Email

dramal4e4i@gmail.com

City

-

Orcid

-

First Name

Reda

Last Name

Mabrouk

MiddleName

R.

Affiliation

Directorate of Health Affairs in Buhaira-Clinical Research Department, Ministry of Health and Population, Damanhur, Egypt

Email

redaessa422@yahoo.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

48832

Issue Date

2024-06-01

Receive Date

2024-04-04

Publish Date

2024-06-01

Page Start

1

Page End

4

Print ISSN

1110-0133

Online ISSN

2682-2547

Article File

JMALEXU_Volume 45_Issue 2_Pages 1-4.pdf

PDF . 473.3kB

Link

https://jmalexu.journals.ekb.eg/article_363436.html

Detail API

https://jmalexu.journals.ekb.eg/service?article_code=363436

Order

1

Type

Case Report

Type Code

1,487

Publication Type

Journal

Publication Title

Journal of the Medical Research Institute

Publication Link

https://jmalexu.journals.ekb.eg/

MainTitle

Effective Management of Acute Aluminum Phosphide Poisoning in Pregnancy: A Case Study of Dual Therapy Efficacy and Collaborative Care

Details

Type

Article

Created At

26 Dec 2024