Following neurosurgical intervention, meningitis caused by resistant microorganisms progresses with substantial morbidity and mortality. Treatment is challenging because there are few antibiotics that can cross into the cerebrospinal fluid and act on these organisms. It is advised to administer intraventricular antibiotics in the treatment of meningitis. Hereby, we are presenting a 2-month-old infant presented to the hospital with fever, hypoactivity and decrease in oral intake. This infant had inserted a shunt a month before this presentation. Upon full examination, the infant was diagnosed to suffer from a meningitis caused by multiple organisms including MRSA, MDR E. coli and MDR Klebsiella pneumoniae. The infection was successfully managed with a combination therapy which included, vancomycin, meropenem, amikacin and later on colistin through different routes of administration.