Meningitis is the infection of the meninges. It can arise from various pathogens, such as bacteria, viruses and fungi, but bacterial meningitis has the greatest worldwide burden. Fever, headache, vomiting, neck stiffness, photophobia, blurred vision, convulsions and altered mental state are the most predominant symptoms of meningitis. Cerebrospinal fluid analysis is the main diagnostic test for meningitis. Bacterial meningitis is a critical medical condition that necessitates prompt diagnosis and urgent treatment. It is caused mainly by Streptococcus pneumoniae and Neisseria meningitides. Abacterial Meningitis may be caused by viruses, fungi and parasites. Viral meningitis is caused mainly by Non-polio enteroviruses. It generally follows a harmless course and exhibits spontaneous recovery.
Leucine rich alpha-2 glycoprotein (LRG) is a newly discovered biomarker that can be used to identify inflammatory disorders. It is composed of 312 amino acid residues, with 66 of these being leucines. Based on data, we hypothesize that LRG may be a promising new addition to the cytokine network, contributing significantly to the inflammatory process.