Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, it is characterized by cellular damage and the production of pro- and anti-inflammatory mediators, frequently leading to organ dysfunction. Globally, sepsis and septic shock harm millions of people annually, with mortality up to 1:4 (and frequently more) attributed to these serious medical conditions.
A frequent consequence in critically ill patients is sepsis-associated acute kidney damage (S-AKI), which raises the risk of long-term comorbidities and has a very high mortality rate.
Doppler based renal arterial resistive index (RRI) is defined as (peak systolic velocity – end diastolic velocity)/peak systolic velocity. The normal range is 0.50-0.70. Higher values are linked to a worse prognosis in kidney transplant recipients and other renal diseases. Because the index reflects pulsatility in renal arteries, it might be useful for the early detection of microvascular damage occurring in sepsis associated acute kidney injury.
AIM OF THE WORK:
The aim of this study was to detect the predictive value of early renal resistive index (RRI) for occurrence of acute kidney injury in septic patients, and its reversibility if occurred.