In the year 2020, lung cancer was second only to female breast cancer as the most commonly diagnosed cancer in the world and the leading cause of cancer-related deaths. In Egypt, the Global Cancer Observatory (GLOBOCAN) 2020 report places lung cancer as the fifth in incidence (4.9%; 6,538 cases). In terms of mortality, lung cancer was the fourth-leading cause of cancer-related deaths in both sexes and accounted for 6.5% (5,817 cases). Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers. On the other hand, among Head and Neck Cancers (HNCs), the most common pathologic subtype is the squamous cell carcinoma (SCC). In 2018, Head and Neck Squamous Cell Carcinoma (HNSCC) was the seventh leading cause of cancer-related deaths globally. In 2020, Egypt reported laryngeal cancer as the most common HNC, ranking 17th in incidence (1.2%; 1,552 cases) and 15th in mortality (1.2%; 1,061 cases) among all cancers. Over time, the role of immunotherapy has been established in the management of both advanced NSCLC, as well as recurrent and metastatic HNSCC.