Acne vulgaris is an inflammatory condition of the pilosebaceous unit, Pathogenesis of this disease is multifaceted, involving four inter-connected processes: inflammation, increased sebum production, hyper-keratinization of the follicular infundibulum, and proliferation of Cutibacterium acnes. Cutibacterium acnes plays a vital role in the pathogenesis of acne by activating the innate and adaptive immunity. Chemotactic factors and proinflammatory cytokines are produced by immune reactions, resulting in local inflammation and potential scarring. Given that both topical and oral antibiotics against C. acnes have been used for decades, Cutibacterium acnes resistance to used antibiotics, such as erythromycin and clindamycin has been detected with high prevalence in Mediterranean countries mainly due to antibiotic abuse.
AIM OF THE WORK:
To assess the prevelance of antibiotic resistance to macrolides, doxycycline and clindamycin in Cutibacterium acnes of acne patients attending dermatology outpatient clinic at Alexandria Main University Hospital.
PATIENTS AND METHODS:
This is a Prospective Observational Cross Sectional study.
Patients:
This study included 100 patients suffering from moderate to severe acne, patients were recruited from dermatology outpatient clinic at Alexandria Main University Hospital. Fully informed consent was collected from all patients prior to the study.