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325295

A STUDY OF SERUM IMMUNOGLOBULIN LEVELS IN ADULT ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING STANDARD INDUCTION CHEMOTHERAPY

Article

Last updated: 26 Dec 2024

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Abstract

Acute myeloid leukemia (AML) is a heterogenous malignant disease caused by an impaired differentiation of hematopoietic stem cells into myeloid cells leading to accumulation of immature blast cells in the bone marrow (BM), the peripheral blood (PB) and rarely other organs. AML accounts for 80% of adult acute leukemia and is primarily a disease of older adults with an annual incidence rate of 20.1 per 100,000 population in those aged above 65 years.
Induction chemotherapy with anthracycline and cytarabine, is the mainstay for treatment of AML; all trans retinoic acid (ATRA) or arsenic trioxide (ATO) are added in Acute Promyelocytic Leukemia cases (APL). However, induction chemotherapy also induces more prolonged neutropenia in AML patients, favoring infectious complications and deaths. Immunoglobulins (Ig) are produced by B-cells in response to bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances. Decreased serum immunoglobulin levels are associated with lower survival rate in septic patients.

DOI

10.21608/alexpo.2023.247032.1729

Keywords

Acute myeloid leukemia (AML), immunoglobulin, Febrile Neutropenia

Authors

First Name

Nadia

Last Name

Zaki

MiddleName

-

Affiliation

Department of Hematology, Alexandria University

Email

nadiazaki65@yahoo.com

City

-

Orcid

-

First Name

Dalia

Last Name

Nafea

MiddleName

Ahmed

Affiliation

Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Alexandria University

Email

dnafea@hotmail.com

City

-

Orcid

-

First Name

Mayada

Last Name

Moussa

MiddleName

Aly

Affiliation

Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Alexandria University

Email

drmayadaam@live.com

City

-

Orcid

-

First Name

salma

Last Name

imbaby

MiddleName

alaa eldin

Affiliation

Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of medicine, Alexandria university, Egypt.

Email

salmaimbaby@hotmail.com

City

alexandria

Orcid

-

First Name

Sheik

Last Name

Mohungoo

MiddleName

Mohammad Irfaan

Affiliation

Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Alexandria University

Email

mufcfaan@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

4

Related Issue

43723

Issue Date

2023-12-01

Receive Date

2023-11-07

Publish Date

2023-12-01

Page Start

31

Page End

32

Online ISSN

2682-2636

Link

https://alexpos.journals.ekb.eg/article_325295.html

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https://alexpos.journals.ekb.eg/service?article_code=325295

Order

1

Type

Preliminary preprint short reports of original research

Type Code

1,426

Publication Type

Journal

Publication Title

ALEXMED ePosters

Publication Link

https://alexpos.journals.ekb.eg/

MainTitle

A STUDY OF SERUM IMMUNOGLOBULIN LEVELS IN ADULT ACUTE MYELOID LEUKEMIA PATIENTS RECEIVING STANDARD INDUCTION CHEMOTHERAPY

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Article

Created At

26 Dec 2024