A serious organ failure known as sepsis is brought on by a poorly controlled host response to an infection. This study assessed Citrulline role as a marker to sepsis in patients with acute leukemia after induction chemotherapy. The study found that ANC was significantly lower in acute leukemia patientsafter induction chemotherapy compared to controls, and both CRP and PCT levels were significantly higher in acute leukemia patients on the first day of fever compared to the seventh day of fever. Citrulline levels were significantly lower in acute leukemia patients on the first day of fever compared to the seventh day of fever and in controls. Citrulline demonstrated promise as a marker for detecting early bacteremia in patients with acute leukemia.. There were negative correlations between citrulline and APACHE II, and positive correlations between CRP and APACHE II.
AIM OF THE WORK:
This study purpose was to assess citrulline's potential as an early sepsis marker in acute leukemia patients receiving chemotherapy