Ageing can be described as a degenerative process of decline in physical function to maintain homeostasis leading to increased possibility of death. Serum selenium and Glutathione peroxidase show progressively decreased as age increased.
AIM OF THE WORK:
To Study the level of plasma selenium and serum glutathione peroxidase in the elders compared to the young.
SUBJECTS AND METHODS:
Prospective study, recruited 50 participants of both genders, 40 patients aged 65 years and more, and 10 apparently healthy participants aged less than 65 years served as a control group. Baseline demographic and health information, routine laboratory investigations, and blood plasma samples of Selenium (Se) and serum Glutathione peroxidase (GPx) were collected between March 2022 till October 2022.GPx Activity was measured using colorimetric method by spectrophotometry and Se levels were measured using Graphite Furnace (GF500, Australia), At the Medical Research Center at Alexandria main hospital.
• RESULTS:
GPX(p=.001) and Se levels(p < .001) were statistically significant higher in control group compared with elders' group. Significantly negative correlations were obtained between Se with age (t= -0.237, p=.017), and GPx with age (t=-0.267, p=.008) for elders group and non-significant correlations for control group in both Se with age(t= -0.023, p=.929) and GPx with age( t= 0.068, p=.787). Significant positive correlation was revealed between Se and GPx in the elders (t=0.287, p= .004), while in control non-significant negative was obtained (t=-0.244, p= .325).
p= .325