Pregnancy-related hypertensive disorders are still a major global health concern for both mothers and their unborn children.
Preeclampsia is defined: systolic blood pressure (SBP) greater than or equal to 140 mm Hg, diastolic blood pressure (DBP) more than or equal to 90 mm Hg, on two occasions as a minimum four hours apart in a patient who was previously normotensive patient and the co-occurrence of one or both of the resulting new-onset conditions:
• Urine protein: creatinine ratio ≥30 mg/mmol.
• Additional signs of maternal organ dysfunction, such as involvement of the kidneys or the liver, neurological or hemorrhagic issues, or uteroplacental dysfunction.
Lipid metabolic abnormalities have been identified as possible risk factors for the onset and progression of preeclampsia. These risk variables are also present in arthrosclerosis, which may indicate a shared pathogenesis.
The pathophysiology and development of preeclampsia are significantly influenced by lipids and lipid metabolism, including:
• Vascular dysfunction
• Defective trophoplastic invasion
• Triggering inflammatory processes
• Driving ferroptosis