Globally, endometrial cancer (EC) accountsfor4.8% of all cancers diagnosed in women.it is the most common malignancy of the female reproductive tract in developed countries, and the second most common in developing countries..
Most FIGO grade 1 endometrioid endometrial carcinomas (EEC) present with early-stage disease and have an excellent prognosis. However, a minority with early-stage, low-grade disease will demonstrate a more aggressive clinical course.
A priori identification of such cases could allow offering additional treatment to women who may benefit the most.4 EEC are histologically heterogeneous and the morphologic pattern of myometrial invasion may be related to biologic potential. Specifically, myometrial invasion with an infiltrative gland pattern has been recently associated with higher stage, lymphovascular invasion and recurrence.
prognostic parameters in breast, colorectal and ovarian cancers. Endometrial carcinomas may also show a further distinctive invasive pattern, characterized by the presence of microcystic, elongated and fragmented invasive glands.
AIM OF THE WORK:
To detect microcystic, elongated and fragmented (MELF) pattern invasion in endometroid endometrial carcinoma and its association with other clinic-pathological findings.