INTRODUCTION
Carnitine has been also used in the treatment of insulin resistance. Vitamin D has a physiologic role in reproduction including ovarian follicular development and luteinization through changing anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production.
OBJECTIVE
Investigation of the efficacy of combining l-carnitine with vitamin D added to letrozole in comparison to letrozole only for ovulation induction in infertile women with polycystic-ovarian-syndrome (PCOS) as regards the endometrial thickness, ovulation rate, pregnancy rate, rate of mono-follicular development and time to conception.
METHODS
During this study, 94 infertile women were enrolled, after consenting each of them and divided into two groups; Regarding first group participants, they received ovulation induction plus oral-carnitine (3g) supplementation combined with 800 IU vitamin D per day for two cycles or till the conception combined with letrozole, while the second group participants received letrozole as 5mg once daily for five days (from day 3 to 7) after spontaneous or progesterone induced bleeding and increased to 7.5mg in the following cycle if ovulation did not occur.