Critical care medicine has been defined as "a service for patients with potentially recoverable diseases who can benefit from close observation and treatment. The critical care unit (CCU) is a distinct organizational entity for clinical activity and care, operating in cooperation with other departments in a hospital. Evidence revealed that the outcome of patients in CCU is significantly related to different factors, including the severity of the disease, infrastructure, medical staff, nursing care, medical supplies, patient's age, mechanical ventilation, length of stay, complications in CCU, and spreading of antimicrobial-resistant microorganisms. Sustainable improvements in patient safety and managing risks to prevent patient harm become a top priority for health care settings globally. Improving Patient safety in a health care setting is closely related to improving quality of health care. Quality improvement in healthcare is the shared efforts of healthcare experts, patients and their relatives, payers, and organizers to improve patient outcomes.