Multiple treatment options are available for management of laryngeal cancer. For early (stage I and II) larynx cancer, both larynx-sparing surgery (transoral endoscopic or open surgical resection) and definitive radiation therapy (RT) generally offer equivalent local tumor control and survival, Organ-sparing approaches permit larynx preservation in patients with locoregionally advanced cancer of the larynx, but do not provide a survival advantage over total laryngectomy. However, because of the importance of the larynx to speech and swallowing function, most patients with advanced cancer of the larynx (stage III and IV) should be offered the option of organ preservation, unless contraindicated.
Although locoregional control of the tumor one of the most important aims in tumor management nowadays, there is great interest in organ preservation modality of treatment as well as functional preservation.
Aim of the work:
To study the efficacy of organ preservation protocol (induction chemotherapy followed by concomitant chemo radiotherapy) in T3 and T4a squamous cell carcinoma of the larynx and to asses the functions (swallowing and respiratory functions) of the preserved larynx in comparison to swallowing and respiration in patients after surgical management.