Liver fibrosis is one of the most common causes of mortality worldwide. Platelet rich plasma (PRP) is one of the newly emerging modalities that contributes to tissue-healing process.
Aim of the work:
To study the potential effect of platelet rich plasma on hepatic fibrosis induced by thioacetamide (TAA).
Material and Methods:
Material:
18 adult male albino rats were randomly divided into 3 groups:
Group I (control): received intraperitoneal (i.p) saline twice weekly for 7 weeks.
Group II (fibrosis): received i.p injection of TAA (200 mg/kg) twice weekly for 7 weeks.
Group III (treated): received i.p injection of TAA (200 mg/kg) twice weekly for 7 weeks and PRP starting from 4th week of TAA administration to the end of the experiment.
Methods:
• Liver fibrosis was induced by intraperitoneal injection of TAA dissolved in 0.9% normal saline in a dose of 200 mg⁄kg body weight twice a week for 7 weeks. Fifteen rats were used for the purpose of PRP preparation using double centrifugation technique.
• At the end of the experiment, all groups were sacrificed and liver was taken for light microscopic examination by H&E and trichrome stains.