Multiple sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the central nervous system (CNS).
The diagnosis of MS requires objective evidence of CNS lesions disseminated in time and space.MS lesions may occur in any part of the central nervous system where myelin exists, but lesions around the ventricles and the corpus callosum are highly suggestive.
.MRI remains the most important paraclinical tool available to support the diagnosis and monitoring of MS.Contrast-enhanced MRI is regarded as the best indicator of disease activity and response to therapy, being used during the treatment course and follow-up of MS patients
CE-FLAIR is more sensitive than CE-T1WI for some enhancing MS plaques.FLAIR sequence is more sensitive to T1 shortening than T1WI at lower concentrations of Gadolinium.Additionally, the use of subtraction method to detect the change in disease burden in MS (using nonisotropic voxels) appears to be efficient and reliable.
AIM OF THE WORK:
The aim of this work was to assess the value of contrast enhanced fluid attenuated inversion recovery magnetic resonance sequence in detection of brain lesions in multiple sclerosis patients.