Dry eye disease (DED) is a usual occurrence in everyday practice,with a significant effect on an individual's quality of life.Commercially available artificial tears eye drops help to relieve the biomechanical trauma caused by DED, but they lack biological properties like nutrients that enhance ocular surface regeneration and immunological defense. As a result, it greatly increased the demand for human blood-derived products as DED eye drops. Serum is the commonly blood product applied as eye drops, with the proposed advantage being the existence of growth factors in tears, which were present in serum, as well as different biochemical components that act similarly to real tears than the usual therapies.They also lack the preservatives found in artificial tears.Other blood-based preparations, such as PRP eye drops, have recently become available as potential therapies for various ocular surface disorders, including DED.
Aim:
The aim of this work was to compare between platelet-rich plasma (PRP) and autologous serum 20 % (AS) eye drops for the treatment of severe dry eye disease.