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ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS

Article

Last updated: 26 Dec 2024

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Tags

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Abstract

• Colorectal cancer (CRC) is the third most common malignancy worldwide
• In Egypt, CRC is the 7th commonest cancer.
• The CRC is the second deadliest cancer worldwide.
• Screening for early cancer stages is an effective way to reduce cancer mortality
• Development of new biomarkers for noninvasive screening procedures is aid to early diagnosis of cancers and to help in reducing mortality and morbidity.
• Non-coding RNA is a functional RNA that does not encode a protein
• Non-coding RNAs are classified into small non-coding RNAs such as small nuclear RNA (snRNA) and long non-coding RNAs
• SnRNAs are known as U small nuclear RNA
• U2 snRNA fragments proved to be highly stable in the serum, plasma and other body fluids from cancer patients and could be detected by a simple routine PCR-based assay
• Detection of U2 snRNA fragments in the blood can also hold promise for detecting some cancer types at a curable stage.

DOI

10.21608/alexpo.2023.188710.1548

Keywords

Colorectal cancer (CRC), U2 snRNA fragments, PCR-based assay

Authors

First Name

Doaa

Last Name

Hahad

MiddleName

Ibrahim

Affiliation

clinical and chemical pathology, Alexandria faculty of edicine, Alexandria University, Alexandria, Egypt

Email

doaa_hashad2003@yahoo.com

City

alexandria

Orcid

-

First Name

Eman

Last Name

Dessouky

MiddleName

Tayea

Affiliation

Clinical and chemical pathology, Alexandria Faculty of medicine, Alexandria University, Alexandria, Egypt

Email

emantayae@yahoo.com

City

alexandria

Orcid

-

First Name

Ahmed

Last Name

Sabry

MiddleName

Abdelfattah

Affiliation

Department of Git surgery, faculty of medicine, Alexandria university

Email

ahmedasabry@yahoo.com

City

-

Orcid

-

First Name

Maha

Last Name

Mohsen

MiddleName

Moustafa Mohamed

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University

Email

maha.fareed22@gmail.com

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

38639

Issue Date

2023-01-01

Receive Date

2023-01-21

Publish Date

2023-01-01

Page Start

14

Page End

15

Online ISSN

2682-2636

Link

https://alexpos.journals.ekb.eg/article_282711.html

Detail API

https://alexpos.journals.ekb.eg/service?article_code=282711

Order

1

Type

Preliminary preprint short reports of original research

Type Code

1,426

Publication Type

Journal

Publication Title

ALEXMED ePosters

Publication Link

https://alexpos.journals.ekb.eg/

MainTitle

ASSOCIATION OF PLASMA (U2) SMALL NUCLEAR RNA FRAGMENTS AND COLORECTAL CANCER IN A COHORT OF EGYPTIAN PATIENTS

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Type

Article

Created At

26 Dec 2024