Neonicotinoids are the most used insecticides worldwide, either as an in-furrow treatment or as a systemic safeguard for seedling crops against chewing and piercing-sucking insects on various crops, including a spectrum of fruits and vegetables. Dinotefuran is a third-generation neonicotinoid. dinotefuran acts on target organisms through gastric poisoning and contact. Given the strong endogenous penetration ability, efficient and long function time, wide insecticidal spectrum, and relatively low toxicity of dinotefuran on mammals, it is commonly used in agricultural production to control the number of various pests such as beetles, lacewings, and aphids dinotefuran is toxic to earthworms, honeybees, and zebrafish