: Eleven wheat cultivars were evaluated against yellow rust disease at two different locations in Egypt i.e. Shibin El-Kom, Minufiya governorate and Itay El-Baroud Agricultural Research Station, Behira governorate, Egypt during three successive growing seasons i.e. 2018/2019, 2019/2020 and 2020/2021. Correlation between weekly eight environmental factors; solar radiation, total precipitation, average wind speed, maximum wind speed, minimum air temperature, maximum air temperature, minimum relative humidity and maximum relative humidity to yellow rust severity (%) was determined using step wise regression analysis. Predictive models for each tested variety to final yellow rust severity disease (%) using environmental data were determined. In general, maximum relative humidity was positively correlated with final yellow rust severity (%). Significant correlation between two environmental factors maximum relative humidity and final yellow rust severity (%) was found in this study. Meanwhile, negative correlation was found between final yellow rust severity (%) and the two environmental factors i.e. solar radiation and minimum relative humidity. High values of R² for all regression models under study referred to the validation of these models to predict yellow rust severity (%) and facilitate the use of each as a warning forecast to wheat farmers