Rust disease of common bean caused by Uromyces appendiculatus is very destructive diseases which affect the plant growth and yield production. This study was conducted in order to find out the available safe methods to control this disease. The obtained results could by summarized as following: 1- Paulista bean cultivar showed the highly susceptible to rust disease fungus both in 2018 and 2019 growing seasons where the average severity of infection recorded 82% at 2018 growing season. 2- Nebraska bean cultivar was the least susceptible one to the disease which resulted 42.3% as average of infection severity in 2018 growing season. 3- Similar results were obtained also in 2019 growing season.