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380035

Potential Effect of Apricot Kernel Powder on Hepatocarcinomic rats Induced by Potassium Bromate التأثير المحتمل لمسحوق نوي المشمش علي الفئران المصابه بسرطان الكبد المستحث بواسطه

Article

Last updated: 26 Dec 2024

Subjects

-

Tags

الاقتصاد المنزلى

Abstract

Apricot kernels are rich in protein and fat, and many anti-cancer compounds. The current study was designed to examine the potential impact of apricot kernel powder (AKP) on rats with cancerous livers induced by potassium bromate. Thirty adult male albino rats, with an average weight of 150±10 g, were divided randomly into two main groups. Group 1 was given a standard diet and served as the negative control group (normal rats). Group 2 was administered a single intraperitoneal dose of potassium bromate at 125 mg/kg body weight to induce oxidative stress and follicular cells, then divided into 4 subgroups. Group 2 remained as the positive control group and received only the standard diet, while groups 3, 4, and 5 were given AKP at concentrations of 10%, 20%, and 30%, respectively. Throughout the 28-day experimental period, each rat's weight was monitored individually, and at the end of the study period, the rats were euthanized, and blood samples were collected. Biological and biochemical parameters were evaluated, and the potential cytotoxic activity against liver carcinoma cell line was measured. The outcomes demonstrated inhibition and repression at consume of AKP at some tumor parameter, as Interferons alpha (IFN-alpha), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), Protein carbonyl oxidation (PCO), Alpha-fetoprotein (AFP) and improving at oxidative parameters and liver function and lipid profiles. The best results were for groups fed with 30% of AKP.

DOI

10.21608/sjsep.2024.310487.1130

Keywords

Apricot kernels, Tumor, Potassium bromate, Hepatocarcinoma

Authors

First Name

Samah

Last Name

El-banna

MiddleName

-

Affiliation

كلية الاقتصاد المنزلي جامعة المنوفية

Email

samahelbanna1990@gmail.com

City

-

Orcid

0009-0007-4187-2541

First Name

Shaimaa

Last Name

Elmesilhy

MiddleName

-

Affiliation

قسم التغذيه وعلوم الاطعمه/كليه الاقتصاد المنزلي / جامعه المنوفيه / مصر / شبين الكوم

Email

shaymaa.abd@hec.menofia.edu.eg

City

المنوفيه

Orcid

-

First Name

Amal

Last Name

Nasef

MiddleName

-

Affiliation

قسم التغذيه وعلوم الاطعمه/كليه الاقتصاد المنزلي / جامعه المنوفيه / مصر / شبين الكوم Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University,

Email

amal.nasif1@hec.menofia.edu.eg

City

-

Orcid

0000-0002-7054-8659

Volume

19

Article Issue

19

Related Issue

46970

Issue Date

2024-06-01

Receive Date

2024-08-07

Publish Date

2024-06-01

Page Start

2,092

Page End

2,128

Print ISSN

2735-3893

Online ISSN

2735-363X

Link

https://sjsep.journals.ekb.eg/article_380035.html

Detail API

https://sjsep.journals.ekb.eg/service?article_code=380035

Order

380,035

Type

أبحاث علمیة

Type Code

1,407

Publication Type

Journal

Publication Title

المجلة العلمية لعلوم التربية النوعية

Publication Link

https://sjsep.journals.ekb.eg/

MainTitle

Potential Effect of Apricot Kernel Powder on Hepatocarcinomic rats Induced by Potassium Bromate التأثير المحتمل لمسحوق نوي المشمش علي الفئران المصابه بسرطان الكبد المستحث بواسطه برومات البوتاسيوم

Details

Type

Article

Created At

26 Dec 2024