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EFFECT OF DIETARY INTERVENTION WITH SEEDS AND SPROUTS OF BROCCOLI ON THE NONALCOHOLIC FATTY LIVER IN THE ALBINO RAT MODEL

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Food and technology as well as Dairy and technology scientific researches

Abstract

: Nonalcoholic fatty liver disease (NAFLD) affects approximately one billion individuals globally, highlighting a pressing need for effective preventive and therapeutic strategies. Broccoli, recognized for its exceptional nutrient profile, is rich in polyphenols, flavonoids, and isothiocyanates, with broccoli sprouts particularly noted for their high sulforaphane content—a compound with demonstrated health benefits. Long-term broccoli consumption has been shown to regulate liver lipid metabolism and mitigate hepatic lipidosis. This study aimed to evaluate the effects of broccoli seeds and sprouts on biochemical markers in a rat model of induced NAFLD. Thirty adult male albino rats were randomly assigned to six groups: negative control, positive control, and four experimental groups supplemented with 2.5% or 5% broccoli seeds (SG1, SG2) or sprouts (BG1, BG2) for 28 days. Results indicated improved body weight gain across all treatment groups, with no significant differences observed between 5% seed and 2.5% sprout groups. Biochemical analyses revealed that the BG2 group exhibited the most favorable reductions in total cholesterol and triglycerides, while HDL levels improved significantly in SG2 and BG2. Liver enzymes (ALT and ALP) decreased markedly in SG2 and BG1. These findings suggest that daily consumption of broccoli seeds and sprouts enhances liver health, supporting their potential role in preventing hepatic damage and managing fatty liver disease

DOI

10.21608/mjfds.2024.324564.1014

Keywords

: Broccoli sprouts, Sulforaphane, Polyphenols, Flavonoids, isothiocyanates, hepatic lipidosis, liver health, Hepatoprotective, dietary intervention, Functional foods

Authors

First Name

Khaled

Last Name

Shaheen

MiddleName

Ali

Affiliation

Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University

Email

drkhaledaly2004@yahoo.com

City

-

Orcid

-

First Name

Mai

Last Name

Gharib

MiddleName

Abd-Alkhalik

Affiliation

Nutrition and Food Sciences department- Faculty of Home Economics- Menofia University

Email

mai.ghareb@hec.menofia.edu.eg

City

-

Orcid

0000-0002-4793-1115

First Name

Mona

Last Name

Elgazzar

MiddleName

Khaled

Affiliation

Nutrition and Food Sciences Dept., Faculty of Home Economics – Menoufia University

Email

kmona2022@gmail.com

City

-

Orcid

-

Volume

9

Article Issue

5

Related Issue

51755

Issue Date

2024-11-01

Receive Date

2024-09-28

Publish Date

2024-11-27

Page Start

45

Page End

54

Print ISSN

2357-0792

Online ISSN

2735-3486

Link

https://mjfds.journals.ekb.eg/article_393828.html

Detail API

https://mjfds.journals.ekb.eg/service?article_code=393828

Order

1

Type

original papers

Type Code

1,406

Publication Type

Journal

Publication Title

Menoufia Journal of Food and Dairy Sciences

Publication Link

https://mjfds.journals.ekb.eg/

MainTitle

EFFECT OF DIETARY INTERVENTION WITH SEEDS AND SPROUTS OF BROCCOLI ON THE NONALCOHOLIC FATTY LIVER IN THE ALBINO RAT MODEL

Details

Type

Article

Created At

26 Dec 2024