Since the 1st century, Hawthorn, a Crataegus plant, has been used to treat heart disease. Both leaves and blossoms are used in modern medicine. Hawthorn may help manage mild to moderate heart failure, so the current study aims to Promote cardiovascular health using different levels of Hawthorn (Crataegus oxyacantha) in heart disorder rats. Thirty (30) Male albino rats of the Sprague-Dawley strain weighing 150±10g, ten weeks old were separated into four groups, one of them as negative control (normal), and other groups were treated with adriamycin (ADM) for two days a week by intraperitoneal injection (five mg/kg) two time per week throughout two weeks, to induce CVD. One of the adriamycin-induced CVD groups was assigned as a positive control group and fed the standard diet, and the remaining three groups were fed 7%, 10%, and 15% Hawthorn for twenty-eight days. Upon completion of the investigation, the blood samples were collected for biochemical analysis. The results indicate that exposure rats to ADM that fed on basal diet +15 % Hawthorn led to a significant increase in the levels of TC, TG, LDL, and VLDL in the blood serum, as opposed to HDL. Also Rats were fed a diet supplemented with a distinct concentration of Hawthorn resulting in a significant reduction (P below 0.05) the level of creatinine & urea serum.