: This study was conducted to investigate the effect of tested dietary formulas on restoring antioxidant levels in rats that were injected with nicotine.  Fifty male albino adult rats (150±10 g) were used. Rats were fed on basal diet for 7 consecutive days and then divided into two main groups. The first main group (5 rats) fed on a basal diet as a control negative group (-ve) (group 1), while the second main group (45 rats) was injected with nicotine subcutaneously for 7 days. The second main group divided into nine groups (5 rats each). Group (2) (control positive group +ve) fed on basal diet also and eight other rats groups fed on supplemented diet with (prickly pear seeds + sunflower seeds + celery seeds) (1:1:1) (5 & 10%), (prickly pear germinated seeds + sunflower germinated seeds + celery germinated seeds) (1:1:1) (5 & 10%), (cape gooseberry + carob+ doum) (1:1:1) (5 & 10%) & (prickly pear peel + cabbage leaves + celery leaves) (1:1:1) (5 & 10%) respectively for four weeks. At the end of the experiment, biological evaluation (BWG, FI & FER), oxidative stress parameters, CRP, lipids profile & liver enzymes were estimated. The results indicated that nicotine injection caused significant decreases in BWG, FI, FER, SOD, GPx, CAT & HDL. while significant increases were recorded in MDA, CRP, TC, TG, LDL, VLDL, AST, ALT & ALP. Injected rats groups treated with various diets revealed improvement in all previous parameters.