A field experiment was conducted at Al-Hussainiya Station -Agricultural Research in Sharkia Governorate, focusing on the effects of chemical compounds and irrigation levels on soil properties, water use efficiency, and productivity of wheat crop (Misr-1 cultivar) grown in clay saline soil. The study included 24 treatments with three replicates, divided into four main plots (irrigation treatment) and six sub-plots (foliar treatments of stress regulators). The physical and chemical properties of the soil were estimated before planting and after harvesting, and growth and yield parameters of each crop were calculated. The water use efficiency and harvesting index were determined. The results showed that the highest productivity for both straw and grain was associated with 100% of the field capacity, followed by the 110%, 90%, and 80% as a general average. There was no clear trend for water use efficiency for both straw and grain, indicating wheat's sensitivity to shortage and surplus in soil water. The effect of transpiration reducers on soil properties and yield of straw and grain of wheat crop was also found to be higher with sprayed treatments compared to the control one. The positive effect of spray with transpiration reducers was generally as follows: potassium silicate, magnesium silicate, salicylic acid, proline, and ascorbic acid. Under salt-affected soil conditions, the relative change of the effect of transpiration reducers on wheat plants was better than the control, with results found with yield, water use efficiency, and harvesting index. The study recommends using potassium and magnesium silicate and an irrigation rate of 100% of the field capacity in the saline clay lands of Al-Hussainiya Plain.