This investigation was carried out in a greenhouse at the Experimental Farm of Faculty of Agriculture, Menoufia University, Shebin El-Kom, Egypt during the two growing seasons of 2021 and 2022 to study the influence of dried sewage rates [0, 5, 10  and 20% (w/w, sewage: soil], irrigation with magnetized water and their interactions on some vegetative growth parameters, plant water relations and membrane stability (permeability), photosynthetic pigments, some biochemical compositions, some nutrient minerals of rocket (Eruca sativa L.) plants as well as behavior some heavy metals and their effect on human health.  One sample was successively taken at random from every treatment at 60 days from sowing. The obtained results showed that sewage sludge increased most growth characters, RWC, LWD, OS, TR, total soluble sugars, total protein, polyphenol oxidase activity, proline and N, P, and K content, meanwhile DSc. MI, photosynthetic pigments and peroxidase activity were decreased. Application of sewage sludge caused a great increase in the concentration of Pb and Cd in the different organs of rocket plant over the safe limits. The irrigation with magnetized water and its interaction with sewage sludge caused an additive enhancement in the growth, some physiological, biochemical characters i.e. (photosynthetic pigments, sugars, total protein, total free amino acids, proline, activity of enzymes, N, P and K mineral status) as well as improved plant water relations and membrane permeability of rocket plants. Under the same condition, there were remarkable decreases in leaf water deficit, transpiration rate, Pb and Cd concentrations and uptake, BCF, TF and CR in rocket plants. Also, the magnetized water under the SS conditions has crucial role in improvement and enhancement the growth, biochemical constituents, a great reduction in Pb and Cd conc. in all organs especially shoot system of rocket plants and become safe for human consumption