ABSTRACT: A field experiment was carried out in 2021 season and repeated in 2022 season at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, Egypt to assess the effect of using hill spacing and topping time in addition to their interactions on productivity and quality of cotton cultivar Super Giza 97 (Gossypium barbadense L.). The experimental design was a split-plot with 3 replicates. The main plots were devoted to hill spacing (25, 30 and 35 cm), whereas plant topping time (no topping, manual topping at the formation of 12, 14 and 16 fruiting branches/plant) was allocated in the sub-plots. Data indicated that the widder hill spacing (35 cm) significantly increased total bolls number set/plant and bolls setting%, yield of seed cotton per feddan and its contributory characters as well as fiber length. However, plant height, bolls shedding% and the number of actual plants per feddan at harvest in both seasons were decreased. No topping treatment gave a significant excess in the final plant height and sympodia number/plant in the two seasons of study. Topping when 16 fruiting branches were formed on the plant gave a significant decrease in bolls shedding% and significant increase in numbers of total fruiting points and total bolls set/plant and bolls setting%, yield of seed cotton per feddan and its contributory characters in the two seasons in addition to length in the first season. Sowing cotton at 35 cm between plants interacted with topping cotton plants just after the formation of 16 fruiting branches gave the best results. It could be advised to apply this interaction treatment under Sakha region, to increase cotton productivity of cotton cultivar Super Giza 97.