Hospital buildings are very complex in nature. Hospital requirements are changing rapidly because of medical, epidemiological, and technological changes. Also, future uncertainties of medical and diagnostic equipment in terms of its size, weight, the environment required for its function, and adjacencies to other functional areas are often a challenge for the hospital designer. Hospital buildings must be designed in a flexible way so as to address these future uncertainties and be able to adapt to changing requirements, the most important of which is epidemiological change. Therefore, the research aims to identify design strategies to achieve flexibility in hospitals and ensure that hospitals adapt to epidemiological changes. By defining flexibility assessment criteria and tools, analysing them, and applying those strategies during the design process to provide more flexible spaces. The research followed a three-part methodology: (1) A historical approach: collecting a theoretical background on the definition of resilience, its principles, and strategies in hospitals (2) Descriptive approach: identifying tools and criteria for assessing global resilience in hospitals (3) A comparative analytical approach: by analysing the global resilience assessment tools in hospitals and the collected theoretical background and making a comparison to identify points of strength and weakness, to apply them in the design and planning of future hospitals.