Small and Medium Enterprises (SMEs) closing is a big problem in Egypt. It is a complex process to keep Small and Medium Enterprises alive, especially with low profits. Small and Medium Enterprises play an important role in a country's economy, making a diversification in jobs, works and decreasing unemployment. This research attempts to solve this problem. The Factors that affect the profits of Small and Medium Enterprises collected and analyzed. The previous research indicates that Business intelligence tools help decision-makers to keep their companies survive and showed a necessary insight into all operations of their companies. The analysis results show that entrepreneur characteristics, External Factors, resources and funds, management and skills experience have a direct effect on Small and Medium Enterprises' profits. The result of this research can be used to enhance, develop, increase the number of small and medium enterprises and profits of these projects and provide them with the best advice to keep them alive.