This study investigated the main determinants of sustainable development in Egypt using annual data for Egypt for the period of 1977 to 2019. The study used the autoregressive distributed lag model (ARDL) for the analysis and the bounds test for cointegration to test whether a long run relationship exists between the study variables - Economic Growth (EG), Unemployment Rate (UNR), Trade Openness (TO), Population Growth (POPG). The main result from the study was that a long and short run relationship exists between the variables, there is a long-run co-integration relationship between the dependent variable Sustainable Development(SD), and the independent variables: Trade Openness, Real GDP Per-Capita, Population Growth, Unemployment Rate (UNR) included in the study, and they have a significant effect on sustainable development. Secondly, the estimated coefficients of  Economic Growth (EG) and Trade Openness (TO) both positively impacts sustainable development in the long run, while Unemployment Rate (UNR) and Population Growth (POPG) both negatively influence sustainable development in long run. In the short run all variables of the study Economic Growth (EG), Trade Openness (TO), Unemployment Rate (UNR), and Population Growth (POPG) negatively-inversely- influence sustainable development. The results also showed that there were no econometrics problems in the model. The results suggest that developing the economy while stimulating trade and promoting policies to decrease Unemployment Rate (UNR) and Population Growth (POPG) will promote sustainable development in Egypt.