Landslides is one of the most important and common natural hazards which facing the Southern Sinai Region. This due to the geological and geomorphological characteristics. That it can have negative impact on infrastructure, especially roads, economic, urban and social projects in the study area. So, the study aims to determine the locations, their areas, and the exposures degrees to this natural hazard, along the Southern Sinai, generally. For avoiding to these sites or handling with this problem by the best methods, when setting to the development projects. Accordingly, it was studied many key-criteria which including numbers of sub-criteria. Divided into, topographic criteria as elevations, slope, aspect, climatic criteria including the amounts of rainfalls, temperature, geological and geomorphological criteria which lithology, geological structures, geomorphology of earth's surface, the surface water and groundwater factors where streams, springs, wells, and, the landcover criteria, especially, vegetation and agricultural lands. The (weighting overlay method) has been followed between all of these criteria represented in the form of produced thematic layers, to achieve the aim of the study. Furthermore, it has been detected the impacts of climate change on the landslide zonation in south of Sinai. By comparing the effects of rainfall and temperature on landslide in the periods 1961: 1998 with their counterpart in 1999: 2021. For more detailed study, it was made overlay between the arid valley basins map and the landslides map overall the studying area. And, extract the data of each valley, separately. Then, compare between them to know the most and the least exposed valleys to landslides. Finally, model builder has been designed, illustrates and helps to study the landslides. It can be applied on any region, especially the arid regions.