Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the third leading cause of cancer-related death worldwide. Aim of the work: To assess the potential value of combining PET/CT and complementary MRI in the follow-up of HCC treated by trans-arterial chemo-embolization (TACE). Patients and Methods: This prospective study was done including forty patients having HCC treated by TACE. These patients were examined by 18F-FDG PET/CT combined with complementary MRI. PET/CT and MRI findings were analyzed. As a result, the included patients were divided into four groups; true positive, true negative, false negative and false positive. Serial alpha-fetoprotein levels were also reviewed. Results: By combining PET/CT and MRI findings, results were true positive in 14 patients, true negative in 14 patients, false negative in 9 patients and false positive in 3 patients. Consequently, true results represented 70%; whereas, false results represented 30%. Conclusion: The combination of PET/CT and complementary MRI did not have any added value in the follow-up of HCC after TACE.