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351760

Parametric Frailty Models for Elapsed Time between Recurrent Events

Article

Last updated: 04 Jan 2025

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Abstract

Analyzing recurring event data is crucial in clinical, epidemiological, and a wide range of other fields, requiring consideration of the interdependence among events within individuals and potential variability in event likelihood across different individuals. This paper introduces a comprehensive suite of models aimed at addressing the gap in parametric frailty models designed for recurrent events. The proposed models encompass five distinct baseline intensities and integrate gamma, inverse Gaussian, and positive stable frailty distributions. Parameter estimation is optimized for maximizing the marginal log-likelihood and accommodates both right-censored and potentially left-truncated data. Model selection is facilitated through the Aikake Information Criterion (AIC) and Bayesian Information Criterion (BIC). Simulation studies assess the computational algorithm and the efficacy of the proposed models. The models' performance is further demonstrated through the analysis of a dataset focusing on recurrent outcomes of phototherapies. Among the proposed models, the one based on a gamma frailty and Weibull baseline intensity stands out with a lower AIC and BIC, establishing it as an enhanced and robust framework for capturing underlying patterns in eczema datasets. The estimates within this model include baseline intensity parameters, incidence relative risk for potential covariates, and the frailty's variance. Beyond capturing the effects of risk factors, the frailty's variance indicates the presence of unobserved heterogeneity in recurrent events not accounted for by the risk factors in the model. The extensive evaluation, involving simulation studies and real-world data analysis, underscores the utility and effectiveness of these parametric frailty models, making a significant contribution to the field of survival analysis

DOI

10.21608/caf.2024.351760

Keywords

Parametric Frailty Models, Baseline Intensity, model selection, Recurrent Events, Frailty Distributions

Authors

First Name

khaled

Last Name

bedair

MiddleName

-

Affiliation

Tanta University

Email

khaled.bedair@commerce.tanta.edu.eg

City

tanta

Orcid

-

First Name

Dina

Last Name

Abdelhady

MiddleName

-

Affiliation

Faculty of Commerce, Tanta University

Email

dina.abdelhady@commerce.tanta.edu.eg

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

47083

Issue Date

2024-03-01

Receive Date

2024-01-01

Publish Date

2024-03-01

Page Start

319

Page End

344

Print ISSN

1110-4716

Online ISSN

2682-4825

Link

https://caf.journals.ekb.eg/article_351760.html

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https://caf.journals.ekb.eg/service?article_code=351760

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351,760

Publication Type

Journal

Publication Title

التجارة والتمويل

Publication Link

https://caf.journals.ekb.eg/

MainTitle

Parametric Frailty Models for Elapsed Time between Recurrent Events

Details

Type

Article

Created At

25 Dec 2024