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397937

Influence of bacterial infection on human sperm

Article

Last updated: 25 Dec 2024

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Abstract

 Background: The invasion of bacteria into the reproductive system of men correlates with diminished sperm functionality, resulting in damaged fertilization capacity. The human body contains trillions of microbes, and their effects on health have been investigated in various bodily systems. There is an agreement regarding the detrimental effects of certain pathogenic bacterial species on semen variables, involving sperm motility, count, morphology, and sperm DNA integrity. This investigation aimed to assess the effects of microbial infection in the male reproductive system on human sperm variables and functioning. This study comprised 186 semen samples from sub-fertile males and unselected couples seeking assistance at the infertility clinic. All semen samples underwent bacteriological examination, and both semen and sperm quality have been assessed following World Health Organization guidelines. (WHO,2010). Results: Among the 186 cases examined for infertility, 65 (34.94 percent) of the analyzed semen samples have been contaminated with various bacterial species. The bacterial strains discovered were Staphylococcus Haemolyticyus, Enterococcus Fecails, Micrococcus Lylae, Escherichia coli, and Serratia marcescens. Infected semen in sub-fertile men adversely affects sperm quality, including motility, count, progression, vitality, and normality. Furthermore, elevated levels of reactive oxygen species (ROS) correlated with diminished sperm functionality, including acrosin activity (A.A) and hypo-osmotic swelling test (HOST) have been observed in infected sub-fertile males compared to their non-infected sub-fertile males, but the differences were statistically insignificant. Conclusion: Infected semen adversely affects sperm parameters and function, resulting in diminished fertilization capability of sperm of humans.

DOI

10.21608/jbaar.2024.312999.1067

Keywords

Infection, Sperm quality, Host, ROS, and Acrosin activity

Authors

First Name

Eman

Last Name

Hassan

MiddleName

A

Affiliation

International Islamic Center for Population Studies and Research. Al-Azhar University. Cairo, 71524, Egypt

Email

emanembryology@gmail.com

City

cairo

Orcid

-

First Name

Yousry

Last Name

Sadeek

MiddleName

K

Affiliation

botany and microbiology department, faculty of science, Al Azhar University

Email

azhari.yosry@gmail.com

City

cairo

Orcid

-

First Name

Tarek

Last Name

Abdelghany

MiddleName

M

Affiliation

Botany and Microbiology Department, Faculty of Science, Al-Azhar University. Cairo. Egypt

Email

tabdelghany.201@azhar.edu.eg

City

cairo

Orcid

-

First Name

Ali

Last Name

Gadel-Rab

MiddleName

G

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Assiut, Egypt

Email

aligamal200992@azhar.edu.eg

City

cairo

Orcid

-

Volume

10

Article Issue

6

Related Issue

52228

Issue Date

2024-12-01

Receive Date

2024-08-16

Publish Date

2024-12-01

Page Start

137

Page End

150

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 10_Issue 6_Pages 137-150.pdf

PDF . 1.1MB

Link

https://jbaar.journals.ekb.eg/article_397937.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=397937

Order

397,937

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Influence of bacterial infection on human sperm

Details

Type

Article

Created At

25 Dec 2024