The study evaluated the level of GLP-1, GIP hormones, and some biochemical parameters in patients with type 2 diabetes compared to healthy individuals and determined the relationship between them. The study included the examination of (83) of both genders, 62 of them were type 2 diabetes patients who were receiving care at the (Diabetes –and Endocrine Clinic at Al-Sader Educational Hospital in Najaf province) and 21 were healthy control, underwent blood tests (CBC, N/L) as well as the biochemical and hormonal indicators included (TC, TG, LDL, HDL, VLDL, GIP, GLP-1). The present study's finding indicated an insignificant rise in white blood cells, platelet count, and N/L count ratio, and a decrease in the patient group's average platelet volume, red blood cell count, and hemoglobin compared with the control group.  As for fat levels, a significant increase in most types of fats was noted in the patient group compared to the control group, the findings of the present study indicate a significant reduction in concentration levels of hormones GLP-1 and GIP in diabetic patients compared to the control group.  Through the results of the current study, we conclude that a decrease in the hormones GIP and GLP-1 are considered predictive indicators of diabetes, and they also play an important role in achieving a state of homeostasis in the level of fat concentration and some blood parameters.